微生态制剂预防婴幼儿抗生素相关性腹泻临床观察

Observation on the Clinical Effects of Probiotics in Preventing Antibiotic-associated Diarrhea in Children

目的:观察微生态制剂预防婴幼儿抗生素相关性腹泻(AAD)的临床疗效。方法:将142例应用抗生素治疗的支气管肺炎患儿随机分为两组,对照组62例,给予常规抗感染治疗;预防组80例,在对照组常规抗感染治疗基础上加服枯草杆菌二联活菌颗粒。年龄<6月,1 g/d,～1岁,2 g/d,～3岁,2～3 g/d,均分为2次服用,疗程7～10 d。比较两组腹泻的发生率,观察两组患儿治疗1周后唾液分泌型IgA(sIgA)含量的变化。结果:对照组62例发生腹泻23例(37.10%),预防组80例发生腹泻13例(16.25%),两组比较差异有统计学意义(χ2=8.021,P<0.01);发生腹泻次数对照组为(5.16±1.50)次/d,预防组为(3.62±1.10)次/d,两组比较差异有统计学意义(t=3.231,P<0.01);腹泻平均持续时间对照组为(4.74±1.32)d,预防组(3.71±1.33)d,两组比较差异有统计学意义(t=2.248,P<0.05)。治疗1周后,对照组唾液sIgA与治疗前比较显著降低(t=2.759,P<0.01),而预防组与治疗前比较差异无统计学意义(t=0.485,P>0.05)。结论:微生态制剂能有效预防婴幼儿AAD。

Objective：To observe the clinical effects of probiotics in preventing antibiotic-associated diarrhea（AAD）.Methods：Randomly 142 cases of child inpatients with bronchopneumonia receiving antibiotic therapy were divided into two groups,62 patients of control group,treated by common anti-infective therapy,while 80 patients of prevention group,except for above therapy,given Live Combined Bacillus Subtilis and Enterococcus Faecium Granules with Multivitamines,~ aged 6 months,1 g/d,~ aged 1 years,2 g/d,~aged 3 years,2~3 g/d,all 2 times each day,7~10 days as a course of treatment.Then the diarrhea incidence rates of the two groups were compared and the levels of salivary secretary IgA（sIgA） after treatment 1 week later were examined.Results：Twenty-three patients suffered from diarrhea in 62 patients of the control group（37.10%）,13 patients suffered from diarrhea（16.25%） in 80 patients of the prevention group（χ2=8.021,P0.01）.The diarrhea frequency of control group was（5.16±1.50） times each day while that of prevention group was（3.62±1.10） times each day（t=3.231,P0.01）.The average duration of diarrhea was（4.74±1.32） days in the control group and（3.71±1.33） days in the prevention group（t=2.248,P0.05）.After one week,salivary sIgA reduced significantly in control group（t=2.759,P0.01）,but there was no significant changes in prevention group（t=0.485,P0.05）.Conclusions：Probiotics can be used to prevent AAD in infants.