健康体检者2型糖尿病高危人群早期筛查及危险因素分析

Screening of risk factors for type 2 diabetes in general population

2009年3月至2010年12月在我院体检者10450人中，糖尿病高危组9016例，其中糖代谢异常检出率15．74％（1420／9016），新诊断糖尿病3．36％（303／9016），糖调节受损12．38％（1117／9016）；非高危组1434例，糖调节受损2．58％（37／1434），无新诊断精尿病。糖调节受损和糖尿病检出率随危险因素数量增加而升高，且均有统计学意义（P〈0．01）。Logistic回归分析显示，糖代谢肄常与增龄、腰围、心率、高血压、脂代谢紊乱、高尿酸血症、男性、有糖尿病家族史相关。具有多个危险因素者是糖代谢异常的高风险人群，应为糖尿病预防和筛查的重点人群.

Total 10 450 people received health cheek-up in our hospital from March 2009 to December 2010. The subjects were classified as high-risk for type 2 diabetes mellitus （DM） group （n = 9016） and non-high-risk group （n = 1434）. The rate of new DM was 3.36% （303/9016） and the rate of impaired glucose regulation （IGR） was 12.38% （1117/9016） in high-risk group ; while in non-high-risk group there was no new DM cases, and IGR rate was 2.58% （37/1434）. The detection rate of IGR and DM significantly increased with the increasing rate of risk factor and numbers （P 〈 0. 01 ）. Logistic regression analysis revealed that the abnormal glucose metabolism was associated with age, male, positive family history, heart rate, hypertension, abnormal lipid metabolism and hyperurieaeidemia. The results suggest that subjects with muhiple risk taetors should be the key population liar prevention and screening of type 2 diabetes.