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新生儿缺氧缺血性脑病血清胰岛素样生长因子-1测定的意义 被引量：7

Analysis of Serum IGF-1 Level of Newborns with Hypoxic Ischemic Encephalopathy
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摘要 目的分析胰岛素样生长因子-1(IGF-1)在新生儿缺氧缺血性脑病(HIE)急性期血清含量的变化。方法采用放射免疫法(RIA)检测48例正常对照、46例HIE患儿急性期血清IGF-1含量。结果 HIE急性期血清IGF-1含量显著低于正常对照组(P<0.01)。结论 HIE患儿血清IGF-1含量的降低与HIE的病理生理过程密切相关,可作为HIE诊断辅助依据,IGF-1亦可作为HIE治疗的调控靶点。 Radi Objective To determine the alterations of IGF - 1 levels in newborns with HIE at acute stages. Methods y was performed to detect the IGF - 1 levels in serum isolated from 48eases of normal controls and 46 eases of HIE newborns at acute and recovery period. Results The IGF - 1 levels in HIE newborns were significantly lower than those in controls （P 〈0. 01 ）. Conclusion Decreasing IGF- 1 in HIE newborns is correlated with the pathophysiological procedure of HIE, which could be taken as an index of diagnosis about HIE, or as a target molecule in therapeutic strategy.
作者 彭珊璐 冯国祝 王国香 李晓燕 张莉
机构地区 广东省深圳市坪山新区人民医院儿科
出处 《实用心脑肺血管病杂志》 2012年第4期601-602,共2页 Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词 胰岛素样生长因子-1 新生儿 缺氧缺血性脑病 Insulin - like growth factor - 1 Newborn Hypoxic ischemic encephalopathy
分类号 R722.19 [医药卫生—儿科]
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参考文献5

二级参考文献32

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共引文献65

同被引文献59

  • 1王楸,陈超,刘登礼,杨毅,陈莲.胰岛素样生长因子-1(IGF-1)对缺氧缺血脑损伤新生鼠内源性IGF-1和IGF-1受体基因表达的影响[J].中国当代儿科杂志,2004,6(6):470-473. 被引量：6
  • 2龚放,邹永蓉,王成林,张瑚明,黄兆敏,杨泽凯.缺氧缺血性脑病新生儿血清瘦素、胰岛素样生长因子-1、白细胞介素-6和肿瘤坏死因子-α水平的变化[J].实用儿科临床杂志,2006,21(9):551-552. 被引量：4
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实用心脑肺血管病杂志
2012年 第4期

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