血小板微粒体与缺血性脑卒中的相关性研究进展

Research progress in the correlation of platelet microparticles and cerebral ischemic stroke

血小板微粒体(Platelet microparticles,PMP)是血小板在不同刺激作用下细胞膜脱落所形成的直径小于1.0μm的微粒。血循环的PMP形成、释放及水平反映血小板活化。PMP具有促凝血作用,并且通过将其胞膜上生物活性物质传递给靶细胞,从而影响靶细胞的生物学功能。PMP水平升高被认为是血管性疾病的标志物,如缺血性脑卒中。本文就血小板微粒体在缺血性脑卒中的研究进展作一综述。

Platelet microparticles（PMP） are a heterogeneous population of vesicles（1 μm） generated from the plasma membrane upon platelet activation by various stimuli.The formation,release and level of circulating PMP reveal the platelet activation.The PMP exhibit procoagulant properties and mediate intercellular transfer of bioactive molecules to change the functions of the recipient cell.Elevation of PMP levels is considered now as an important marker of vascular dysfunction,including cerebral ischemic stroke.The objective of this paper is to review the developments of PMP in cerebral ischemic stroke.