原发性肝癌并发肝肾综合征影响因素分析

Analysis of factors of primary hepatic carcinoma complicated by hepatorenal syndrome

目的:分析原发性肝癌并发肝肾综合征的影响因素,以提高对原发性肝癌并发肝肾综合征的早期发现。方法:对75例原发性肝癌死亡患者根据是否并发肝肾综合征分为研究组及对照组,回顾性分析影像学资料及白蛋白、胆红素、PTA、血钠、胱抑素-C等。结果:门脉主干癌栓、肝内多发转移病灶、大量腹水在研究组中分别为59.1%、77.8%、96.3%,对照组分别为29.2%、33.3%、50%,两组之间差异有统计学意义(P<0.05)。研究组低血钠、胱抑素-C升高较对照组明显,两组之间差异有统计学意义(P<0.05)。结论:门脉主干癌栓、肝内多发转移病灶、大量腹水、低钠、胱抑素-C升高的原发性肝癌患者易出现肝肾综合征。

Objective To investigate the possible influence factors in patients with primary hepatic carcinoma complicated by hepatorenal syndrome.Method Seventy-five patients died from primary hepatic carcinoma were enrolled from January 2003 to January 2011 in our department.These patients were divided into two groups.The ones in the research group were complicated by hepatorenal syndrome and the control ones without hepatorenal syndrome.We analyzed retrospectively the imaging and laboratory data,and the later one included albumin,bilirubin,PTA,serum sodium,cystatin-C,etc.Results There were significant differences in tumor-thrombus in the main portal veins（the research group 59.1% vs.the control group 29.2%）,intrahepatic multiple metastases（77.8% vs.33.3%）,massive ascites（96.3% vs.50%）,lower serum sodium,higher serum cystatin-C between two groups.Conclusion Patients with primary hepatic carcinoma would be easier to complicate with hepatorenal syndrome in which accompanied with tumor-thrombus in the main portal veins,intrahepatic multiple metastases,massive ascites,lower serum sodium,and higher serum cystatin-C.