支气管哮喘患者血清SCF、IL-6和TNF-α水平测定及意义

Measurement and Significance of SCF, IL-6 and TNF-α in Serum of Patients with Bronchial Asthma

目的探讨支气管哮喘患者血清干细胞因子(SCF)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)水平变化及意义。方法选择40例支气管哮喘急性发作患者(急性发作组),并按病情严重程度分为轻、中、重、危重组,另选择30例支气管哮喘缓解期患者(缓解组)和20例健康体检者(正常对照组)。采用酶联免疫法(ELISA)分别检测血清中SCF、IL-6和TNF-α的水平。结果急性发作组患者血清SCF、IL-6和TNF-α的水平明显高于缓解组和正常对照组(P均<0.05);缓解组患者血清SCF、IL-6和TNF-α的水平明显高于正常对照组(P均<0.05);急性发作组患者轻、中、重、危重组血清SCF、IL-6和TNF-α水平逐渐升高,组间比较有显著性差异(P<0.05)。结论 SCF、IL-6和TNF-α在哮喘发病机制中可能起重要作用,血清SCF、IL-6和TNF-α的水平可能与哮喘急性发作的严重程度有关。

Objective To investigate the change and significance of stem cell factor（SCF）,interleukin-6（IL-6）,tumor necrosis factorα（TNF-α）level in serum of patients with bronchial asthma.Methods 40 patients with acute exacerbation of bronchial asthma were selected（acute group）,and remission group 30 cases patients and 20 healthy persons（control group） were selected.the serum SCF,IL-6 and TNF-α level of which were measured respectively by ELLISA.Results The serum SCF,IL-6 and TNF-αlevels in acute group were significantly higher than that in control group and remission group（P0.05）;The serum SCF,IL-6and TNF-α levels in remission group were significantly higher than that in control group（P0.05）;The serum SCF,IL-6 and TNF-α levels of slight,moderated,severe and critical groups were increased steply（P0.05）.Conclusion The level of serum SCF,IL-6 and TNF-α may be related to the severity of asthma attack.SCF、IL-6 and TNF-α plays an important role in both pathogenesis and determination of asthma.