肺结核患者下呼吸道医院感染病原菌的分布及耐药性分析

Distribution and antimicrobial resistance of pathogenic bacteria causing lower respiratory tract infections in pulmonary tuberculosis patients

目的探讨肺结核患者下呼吸道医院感染病原菌的分布及耐药现状,为临床选择抗菌药物提供参考依据。方法病原菌培养与鉴定按照《全国临床检验操作规程》进行;药敏试验采用CLSI推荐的K-B法。结果 223株下呼吸道病原菌中,革兰阴性杆菌占78.5%,革兰阳性球菌占16.1%,真菌占5.4%;分离出的病原菌为多药耐药菌,对常用抗菌药物产生了严重的耐药性;MRSA的检出率为57.7%。结论应采取有效的干预措施,降低肺结核患者医院感染的发病率。

OBJECTIVE To investigate the distribution and antimicrobial resistance of pathogenic bacteria causing lower respiratory tract infections in pulmonary tuberculosis patients so as to provide reference for clinical use of antibiotics.METHODS The culture and the identification of pathogens were performed by referring to National Guide to Clinical Laboratory Operation Procedures;the antibiotic susceptibility testing was carried out by using K-B method recommended by CLSI.RESULTS Among 223 strains of pathogenic bacteria causing lower respiratory tract infections,gram-negative bacilli accounted for 78.5%,gram-positive cocci accounted for 16.1%,and fungal accounted for 5.4%.Most of the isolated strains were multidrug-resistant to commonly used antibiotics.The detection rate of MRSA was 57.7%.CONCLUSION Effective interventions should be taken to reduce the incidence of nosocomial infections in pulmonary tuberculosis patients.