摘要
目的:研究不同交联聚维酮性质及其在中药中应用的差异性。方法:选取4种国产交联聚维酮和3种进口交联聚维酮,对其粒子形态、流动性、溶胀性、吸水速度常数、比表面积等进行研究;以穿心莲片、十全大补片、六味地黄片处方为模型,考察不同交联聚维酮崩解性能。结果:不同交联聚维酮在粉体学性质和功能性参数方面均存在一定的差异,尤其作为崩解剂应用于中药中,崩解性能进口交联聚维酮明显优于国产交联聚维酮。结论:国产交联聚维酮性能有待于优化。
Objective：To study on difference of properties of cross-linked povidone（PVPP） and its application in the traditional Chinese medicine.Method： Four kinds of domestic PVPP and three kinds of imported PVPP were chosen,and to study on particle morphology,mobility,swelling capacity,water absorption rate constant and specific surface area,etc;Performance of different PVPP was investigated with Chuangxinlian tablet,Shiquan Dabu tablet,Liuwei Dihuang tablet as model medicine.Result： There were some differences in powder properties and functional parameters of different PVPP,especially it was used in model medicine as disintegrating agent,imported PVPP was better than domestic PVPP on disintegrating performance.Conclusion： Performance of domestic PVPP need to be optimized.
出处
《中国实验方剂学杂志》
CAS
北大核心
2012年第8期18-21,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
中医药行业科研专项(200807032)
关键词
交联聚维酮
性质
差异性
崩解剂
cross-linked povidone
property
differences
disintegrating agent
