血清乳酸脱氢酶早期预测急性胰腺炎继发多器官功能障碍综合征的价值研究

Study for the value of serum lactate dehydrogenase predicting multiple organ dysfunction syndrome caused by acute pancreatitis

目的研究血清乳酸脱氢酶早期预测急性胰腺炎（AP）继发多器官功能障碍综合征（MODS）的临床价值。方法收集2008—10—2011—10我院收治的113例急性胰腺炎住院患者临床资料，通过绘制ROC曲线评价血清乳酸脱氢酶对AP继发MODS患者的预测价值。结果发病48h内，血清乳酸脱氢酶预测AP继发MODS患者ROC曲线下面积0．903（95％CI：0．848～0．959），最佳截断值为：299．3U／L（灵敏度96．43％，特异度76．47％，正确率81．42％）。结论血清乳酸脱氢酶早期预测对AP继发MODS有较高临床价值，通过绘制ROC曲线可以科学确宁其最佳截断值．’

Objective To investigate the clinical value of serum lactate dehydrogenase predicting multiple organ dysfunction syndrome caused by acute pancreatitis. Methods Clinical data were collected from 113 hospitalized patients of acute pancreatitis admitted from Oct. 2008 to Oct. 2011, the clinical value of serum lactate dehydrogenase predicting multiple organ dysfunction syndrome caused by acute pancreatitis was evaluated by plotting the ROC curve. Results ROC curve： AUC 0. 903 （95% CI： 0. 848 -0. 959）, of which the best cut- off value of serum lactate dehydrogenase predicting multiple organ dysfunction syndrome caused by acute pancreatitis within the first 48 h was 299.3 U/L （ sensitivity 96.43%, specificity 76.47%, correctly classified 81.42% ）. Conclusion Serum lactate dehydrogenase was very valuable for predicting muhiple organ dysfunction syndrome caused by acute pancreatitis, of which the best cut - off value could be determined by plotting the ROC curve.