基于中药指纹图谱多维信息的化学模式识别研究进展

Progress on chemical pattern recognition in traditional Chinese medicines by multidimensional information of metabolic fingerprinting analysis

作为一种基于中药化学成分信息,综合的、可量化的鉴别手段,中药指纹图谱已成为国际公认的控制天然药物、中成药质量的最有效的方法;中药化学模式识别则是模糊数学概念渗透到药学领域的重要突破,其在中药质量评价与控制中的运用,解决了中药质量多维信息的综合分析问题,已逐步被更多的人所接受,并不断深入延展开来。随着当代化学分析技术及计算机技术的发展,更多的检测手段应用到中药指纹图谱的构建工作中,更多的化学计量学方法运用到中药指纹图谱的数据处理中来,使得更多的传统中药材、中成药的真伪鉴定、质量评定工作得以实现,且技术已日臻成熟,并取得了诸多成果。该文对20余年来国内外中药指纹图谱模式识别的研究情况作一概述,以期为中药指纹图谱化学模式识别的进一步研究提供参考。

As a comprehensive,quantifiable identification method based on the chemical composition information of traditional Chinese medicine（TCM）,the fingerprint of traditional Chinese medicine has become an internationally recognized effective way to control the quality of natural medicine.Chemical pattern recognition in traditional Chinese medicines is an important breakthrough for the infiltration between fuzzy and pharmaceutical sciences,has been used in the field of quality assessment and control for traditional Chinese medicine.It has solved the problem of comprehensive analysis with multi-dimensional information,and gradually been accepted by more researchers to in-depth study in the further.With the development of modern chemical analysis and computer techniques,there are more technologies were applied to the establishment of fingerprints of traditional Chinese medicine,more chemometric methods have been applied to the data processing of TCM fingerprint,and more quality identification and assessment for TCM to be achieved.And the technology has matured and achieved a lot.In this paper,we make a review for the chemical pattern recognition in traditional Chinese medicines since it be invented,provide a reference for the further research.