胸腺瘤MSCT征象与PCNA及MMP-2表达的相关性

Correlation of PCNA and MMP-2 expression with multi-slice spiral CT manifestations of thymoma

目的:探讨胸腺瘤MSCT征象与增殖细胞核抗原(PCNA)、基质金属蛋白酶2(MMP-2)在胸腺瘤组织中表达的相关性。方法:对46例胸腺瘤患者行MSCT平扫,其中21例行增强扫描,所有胸腺瘤标本行免疫组化SP法染色,分析MSCT征象与PCNA、MMP-2表达水平的相关性。结果:胸腺瘤CT征象中的病灶直径大于10cm,分叶征,病灶边缘不光滑,纵膈脂肪线消失,胸膜、心包及大血管侵犯,纵隔淋巴结、远处转移及病灶高强化程度与胸腺瘤组织PCNA及MMP-2的高表达具有显著相关性(P<0.05)。结论:MSCT征象能在一定程度上反映胸腺瘤的病理学特点,有利于术前无创地评估肿瘤生物学行为。

Objective：To investigate the correlation of proliferating cell nuclear antigen（PCNA） and metris metalloproteinase-9（MMP-2） expression with multi-slice spiral CT（MSCT） manifestations of thymoma.Methods：Fourty-six thymoma patients underwent MSCT scanning,21 of them also had enhanced CT.All of the thymoma specimen had immuno-histochemistry SP staining,the correlation of MSCT findings with PCNA and MMP-2 expression were studied.Results：Significant correlation was observed between high PCNA and MMP-2 expression with the following CT findings such as tumor diameter 10cm,lobulation,ill-defined margin,invasion of pleura,pericardium and great vessels within mediastinum and loss of mediastinal fat,distal/ mediastinal lymph node metastases and marked enhancement（P0.05）.Conclusion：Certain MSCT findings can reflect the pathology characteristics of thymoma,which might be served as a noninvasive modality for preoperative evaluation of thymoma.