子宫腺瘤样瘤的临床病理分析

Clinicopathological Features of Adenomatoid Tumors of Uterus

目的探讨子宫腺瘤样瘤的临床病理特征及鉴别诊断要点。方法对11例发生于子宫的腺瘤样瘤的临床信息、组织病理学特征以及免疫组织化学表型进行回顾性分析。结果患者多为生育期女性,最常伴发的疾病为子宫平滑肌瘤(36.7%)。肿瘤镜下形态多样,可见印戒样细胞、裂隙样腔隙、多囊网状或不规则大囊状结构等。免疫组织化学染色panCK(100%)、calretinin(100%)及HBME-1(82%)强阳性,CK5/6弱阳性(27.3%),而CD31(0)为阴性。主要应与腺癌、平滑肌瘤等相鉴别。结论仔细取材,准确把握其镜下形态及鉴别诊断要点,合理应用免疫组织化学技术,有助于正确诊断该疾病,避免临床的误诊及误治。

Objective To investigate tile clinicopathological features and key points of different diagnosis of Adenomatoid Tumors（ATs） of the uterus. Methods The clinical, histopathological and immunohisto- chemical features were evaluated in 11 cases of ATs retrospectively. Results Most patients were women of child-hearing period.the disease was often accompanied by uterine smooth muscle tumors （36.7%）. A variety of microscopic patterns of tumor including signet ring-like cells, crack like cavities,polycystie re ticular structure and irregular large cystic structure were presented. Immunohistochemical staining showed strong positive for panCK（100%）,calretinin（100%） and HBME l （82%）.weak positive for CK5 6 （ 27.3%） but negative for CD31 （0）. The main different diagnosis was adenocarcinoma and leiomy- oma. Conclusion Careful dissection.accurately grasping of microscopic morphology,key points of differ cut diagnosis and immunohistochemistry techniques are useful in establishing a correct diagnosis of ATs, and avoiding misdiagnosis and mistherapy of clinical managment.