摘要
为探究药物本身及缓释管组成结构等因素对药物缓释速率的影响,以孕酮、睾酮和雌二醇作为缓释试验药物,对硅胶缓释管的封堵方式、管长、管壁厚度以及所填充药物的方式等因素对药物缓释速率的影响进行了检测。实验结果表明,药物的结构对其本身的缓释速率具有决定性作用。硅胶缓释管的封堵方式、管长、管壁厚度及所填充药物的方式都对药物的缓释速率具有显著的调节作用,且调节作用的大小与药物本身缓释性能的大小成正比。另外,我们新研制的玻璃-硅胶缓释管释放面积小,药物储存能力大,特别适用于释放速率较快的药物在体内的长期缓释。
To investigate the effects of the property of drugs and the structure of drug delivery devices on the drug release rate,the effects of sealing methods,length,thickness and drug-loading manner of the silicone tubes on the drug release rate were examined using progestin,testosterone,estradiol as the delivery drugs.The results showed that the property of the drug was the crucial factor to the drug release rate.The sealing methods,length,thickness and drug status of the silicone tubes had significant effects on the drug release rate and the effects were closely related to the property of the drugs.In addition,our newly developed glass-silicone tube has larger drug deposition capability and smaller drug release area,offers an effective and convenient method for the sustained drug delivery with quick release traits in vivo.
出处
《生物医学工程学杂志》
CAS
CSCD
北大核心
2012年第2期296-300,共5页
Journal of Biomedical Engineering
基金
国家自然科学基金资助项目(30872950)
辽宁省教育厅基金资助项目(2008031)
关键词
药物缓释速率
药物缓释管
孕酮
睾酮
雌二醇
Drug release rate
Drug delivery device
Progestin
Testosterone
Estradiol
