运动训练大鼠长期停训后海马细胞核转录因子NF-kBp65的表达变化

Expression Change of NF-kBp65 in Rat Hippocampus after Long-term Stop Trained

应用免疫组织化学技术探讨长期停训对大鼠海马神经元细胞核转录因子(Nuclear factor of kapa B,NF-kBp65)表达的影响。参照Bedford训练方案,建立有氧与疲劳训练动物模型,连续训练8周后,停训28周,观察大鼠海马NF-kBp65的表达变化。结果表明,疲劳训练组大鼠海马神经元NF-kBp65表达上调,疲劳训练促进停训后大鼠海马神经元NF-kBp65的阳性表达。暗示早年疲劳训练可能会影响到大鼠老年期海马组织细胞的功能。

The influence of long-term stopping training on the expression of NF-kBp65 in rat hippocampus neuron was explored by using immunohisyochemistry technique.Refer to the training scheme of Bedford,the training model was set up.After 8 weeks training,all rats lived in the normal cage for 28 weeks.Then the expression change of NF-kBp65 in the Hippocampus Neuron was detected.The results showed that the expression of NF-kBp65 in fatigue training group increased.Fatigue training could promote the expression of NF-kBp65 in CA1 and CA3 area of hippocampus.This result implied that fatigue training in rat early age could affect the functions of hippocampus in old age.