2型糖尿病视网膜病变相关因素Logistic回归分析

Logistic Regression Analysis of the Risk Factors for Diabetic Retinopathy in Type 2 Diabetes Mellitus

目的研究影响2型糖尿病视网膜病变(DR)的相关因素。方法对720例2型糖尿病患者的糖尿病病程、糖尿病家族史、心脑血管病史、吸烟史、居住地域等进行调查,测量血压、血脂、体质指数(BMI)、糖化血红蛋白(HbA1)c、空腹血糖(FPG)、24 h尿微量白蛋白等,检查糖尿病周围神经病变,并对上述DR相关因素进行Logistic回归分析。结果单因素Logistic回归分析结果显示,居住地域、糖尿病病程、血压、糖尿病周围神经病变、HbA1c、24 h尿微量白蛋白与DR发生之间的联系有统计学意义(P<0.05);多因素Logistic回归分析结果显示,糖尿病病程、HbA1c、24 h尿微量白蛋白与DR发生之间的联系有统计学意义(均P<0.05)。结论糖尿病病程、HbA1c、24 h尿微量白蛋白与DR发生相关。

Objective To explore the relevant factors for type 2 diabetic retinopathy （DR）. Methods The relevant factors for DR, including duration, family history, history of cardiovascular and cerebrovascular disease, smoking, residential district, blood pressure, blood lipids, body mass index （BMI）, glycosylated hemoglobin （HbAIc）, fasting blood glucose （FPG）, 24 hours urinary microalbumin and diabetic peripheral neuropathy, in 720 patients with type 2 diabetes mellitus were investigated and analyzed with the logistic regression model. Results Univariate analysis showed that residential district, diabetic duration, blood pressure, diabetic peripheral neuropathy, HbAlc and 24 hours urinary microalbumin were closely related with DR （P〈0.05）; Multivariate analysis exhibited that diabetic duration, HbAlo and 24 hours urinary microalbumin were independent risk factors for DR（P〈0.05 ）. Conclusions The DR is correlated with the diabetic duration, HbA1c and 24 hours urinary microalbumin.