30d头低位卧床对人脑灰质密度的影响

Effects of 30 d Head-down Bed Rest on Density of Human Brain Grey Matter

目的探讨头低位卧床(head-down bed rest,HDBR)对人脑灰质密度的影响。方法 14名男性健康志愿者,进行为期30 d的-6°头低位模拟微重力卧床实验。使用3.0T超导MR成像系统采集卧床前后的高分辨率全脑解剖成像数据,用SPM8软件进行基于体素的形态学分析(VBM),比较志愿者卧床前后的脑灰质密度变化。结果卧床后志愿者双侧丘脑、双侧枕叶、右侧顶下小叶的灰质密度减少(P<0.005)。结论模拟微重力环境可致正常成年人脑灰质密度发生改变。

Objective To investigate the effect of head-down bed rest（HDBR） on density of human brain grey matter.Methods Fourteen healthy male volunteers underwent-6° 30 d HDBR simulated microgravity.High-resolution brain anatomical imaging data were collected with a 3.0 T superconducting MR imaging system before and after HDBR.With voxel-based morphometry（VBM） module of analysis software package SPM8,the pre-and post-HDBR image data of density of whole brain grey matter were calculated and compared.Results After HDBR,the density of grey matter was decreased significantly in the bilateral thalamus,bilateral occipital lobe and right inferior parietal lobule（P0.005）.Conclusion HDBR simulated microgravity may cause density changes in brain grey matter of normal adults.