知柏地黄汤加味对痤疮患者血清睾酮水平的影响

Effect of Zhibai Dihuang Decoction on Levels of Testosterone of Acne Patients

目的:观察知柏地黄汤对痤疮患者血清睾酮水平的影响及临床疗效。方法:将寻常痤疮患者60例随机分为两组,治疗组30例用知柏地黄汤,对照组30例用维胺酯胶囊,治疗8周后,评价其临床疗效及安全性,并观察60例患者治疗前后外周血的睾酮(T)变化。结果:对照组痊愈6例,痊愈率为20.00%,显效7例,有效12例,总有效率为83.75%。治疗组痊愈7例,痊愈率为23.33%,显效9例,有效10例,总有效率为86.67%。两组比较无统计学差异(P>0.5)。其中对照组痤疮患者体内睾酮(T)水平治疗前后有显著变化(P<0.05),且组间比较差异有统计学意义(P<0.05)。结论:知柏地黄汤对寻常痤疮有确实的疗效,其可能机理在于其能调节患者体内睾酮(T)水平。

Objective：To evaluate the efficacy and security of Zhibai Dihuang Decoction on the treatment of ache,and study its effect on the levels of Testosterone.Methods：60 cases of acne patients were randomly divided into therapeutic group and control group,patients of therapeutic group were treated with Zhibai Dihuang Decoction,and control group were treated with Viaminati.After 8 weeks,therapeutic results and changes of serum levels of Testosterone before and after treatment were measured.Results：In therapeutic group,six patients（20.00%） were cured,7 cases showed markedly effective,and total effective rate was 83.75%;in control group,seven patients（23.33%） were cured,9 cases showed markedly effective,and total effective rate was 86.67%,There Was no significant difference（P0.5）.The levels of Testosterone in therapeutic group were greatly different before and after treatment（P0.05）,and it was greatly different from that of control group（P0.05）.Conclusion：Zhibai Dihuang Decoction has preferable clinic effects.It may take the role through regulating the level of Testosterone.