摘要
目的:观察重组人干扰素α2a-NGR(rhIFNα2a-NGR)主要药效学以外的一般药理作用,为临床研究和安全用药提供参考。方法:小鼠、猴和家兔肌内注射rhIFNα2a-NGR后,测试其对动物心血管、呼吸、神经系统和体温的影响。结果:rhIFNα2a-NGR对小鼠的一般行为、自发性活动和猴的血压、心率、心电图、呼吸频率和幅度无显著影响。中剂量可引起个别家兔的体温轻度升高,高剂量可使全部兔体温升高超过0.6℃,与对照组比较差别显著(P<0.05)。结论:rhIFNα2a-NGR对动物心血管、呼吸和中枢神经系统无显著性影响,但对家兔有剂量依赖性致热作用。
Objective： To investigate the general pharmacological actions of recombinant human interferonα 2a-NGR（rhIFNα 2a-NGR） except its main pharmacodynamic properties,and thus to provide experimental basis for clinical study and application.Methods：Mice,monkeys and rabbits were given rhIFNα 2a-NGR for injection respectively via im,and then the influences on cardiovascular,respiratory,central nervous system,and body temperature of animal were determined.Results：At therapeutic dose,rhIFNα 2a-NGR had no obvious effect on general behavior,spontaneous activity,and coordination test in mice,and no obvious effect on blood pressure,heart rate,electrocardiogram,and respiratory rate in anesthetized monkeys（P0.05）.But it slightly elevated the body temperature of a few rabbits treated with medium dose.It also caused body temperature elevation of more than 0.6 ℃ in all rabbits in high dose group.Between 1 and 4 h after administration,the temperature had significantly difference compared with that of control group（P0.05）.Conclusion： Except for the body temperature elevation in rabbits in a dose-dependent manner,rhIFNα 2a-NGR had no effect on nervous,cardiovascular and respiratory systems of the animals.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2012年第7期776-779,794,共5页
Chinese Journal of New Drugs
基金
国家自然科学基金(30572210)
