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吡格列酮、二甲双胍联合胰岛素治疗初诊的肥胖2型糖尿病患者的疗效观察

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摘要 所有入选患者均接受胰岛素泵治疗两周。分为吡格列酮、二甲双胍联合胰岛素组和胰岛素组。记录两组患者的每日血糖监测结果(三餐前、三餐后两小时及睡前血糖)。计算出每组患者的达标率及治疗两周后的胰岛素日用量。治疗两周后,insulin组的血糖达标率为60%(9/15),pioglitazone+met+insulin组的血糖达标率为94.7%(18/19),两组具有显著性的统计学差异(P<0.05)。insulin组胰岛素的日平均用量为(23.1±11.8)μ,pioglitazone+met+insulin组胰岛素的日平均用量为(9.5±7.2)μ,两组具有显著性的统计学差异(P<0.05)。治疗两周后,insulin组有1人(6.7%)停用胰岛素治疗,pioglitazone+met+insulin组有6人(31.6%)停用胰岛素治疗,两组具有显著性的统计学差异(P<0.05)。pioglitazone+met+insulin组患者4人有胃肠道反应但可以耐受。insulin组无胃肠道反应。结论初诊的肥胖糖尿病患者,早期联合吡格列酮、二甲双胍和胰岛素治疗,使更多患者血糖达标,并节约胰岛素用量。同时,吡格列酮、二甲双胍具有较好的耐受性和治疗依从性。
作者 王丹 杨玉芝 江红 冯琨 向朝峰
机构地区 黑龙江省医院内分泌科
出处 《实用糖尿病杂志》 2012年第2期32-33,共2页 Journal of Practical Diabetology
关键词 二甲双胍 胰岛素 2型糖尿病
分类号 R587.1 [医药卫生—内分泌]
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参考文献7

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二级参考文献11

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实用糖尿病杂志
2012年 第2期

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