摘要
目的比较齐拉西酮与利培酮对首发精神分裂症患者生活质量的影响。方法将符合条件的71例首发精神分裂症患者随机给予齐拉西酮和利培酮治疗,用阳性与阴性症状量表(PANSS)评定疗效,副反应量表和相关实验室检查评定副反应,精神分裂症病人生活质量量表评定患者的生活质量。结果治疗后两组患者在PANSS量表减分率相当(χ2=0.40,P>0.05),副反应发生率上无显著差异(χ2=0.40,P>0.05),而齐拉西酮组在改善病人生活质量方面的效果明显高于利培酮组(P<0.01)。结论齐拉西酮在提高精神分裂症患者生活质量方面的效果明显优于利培酮。
Objective To investigate the effect of Ziprasidone and Risperdone on quality of life of patients with schizophrenia.Methods A total of 71 schizophrenia were treated with Ziprasidone or Risperdone randomly.The efficacy was evaluated with Positive and Negative Symptoms Scale（PANSS） and side effects with Treatment Emergent Symptom Scale（TESS） and related lab tests,quality of life with Schizophrenia Quality of Life Scale.Results After treatment,the rate of the scores of PANSS decreased approximately（χ2=0.40,P〈0.05） and there was no significant difference in the side effects caused by two medicines between two groups（χ2=0.40,P〈0.05）,however the quality of life of the patients treated with Ziprasidone were significantly better than those with Risperdone（P〈0.01）.Conclusion Ziprasidone has more advantage than Risperdone to improve quality of life of patients with schizophrenic.
出处
《中国健康心理学杂志》
2012年第2期180-182,共3页
China Journal of Health Psychology
