选择性血管扩张剂对急性脑梗死患者血清IL-6、S100B影响

Selective Vasodilator Therapy Evaluation of Acute Brainstem Infarction on Serum IL-6,S100B Effects

目的:探讨应用前列地尔在治疗脑干梗死急性期对于白细胞介素-6(IL-6)、S100B蛋白表达的影响。方法:用双抗体夹心酶联免疫法测定60例急性脑干梗死患者血清IL-6、S100B蛋白水平变化,并根据神经功能缺损(NIHSS)评分、Barthel指数评分(BI)判断前列地尔治疗对于急性期脑干梗死疗效。结果:前列地尔组在治疗急性期脑干梗死第3天可以显著降低IL-6、S100B的表达,第14天时下降更为显著,同时可以显著降低(NIHSS)评分、提高BI评分,提高疗效。2组比较具有统计学差异(P<0.05)。结论:应用前列地尔可以显著降低IL-6、S100B的表达,改善脑干梗死的预后。

Objective：To investigate Lipo-PGE1 in the treatment of acute brainstem infarction for interleukin -6 （IL-6）, S100B protein expression. Methods： Double antibody sandwich ELISA method in 60 patients with acute brainstem infarction patients IL-6, S100B protein levels and, based on neurological deficit （NIHSS） score, Barthel Index score （BI） to judge Lipo-PGE1 treatment for acute brainstem infarction. Results： Lipo-PGE1 group in the treatment of acute brainstem infarction on the third day could significantly reduce the IL-6, S100B expression on day 14 decreased more significantly at the same time could significantly reduce （NIHSS） score, BI score increased, increase efficacy. Two groups had significant difference （ P 〈 0.05）. Conclusions： Application of Lipo-PGE1 caould significantly reduce the IL-6, S100B expression, to improve the prognosis ofbrainstem infarction.