肠三叶因子对肠黏膜保护与修复的研究

Study on Protective and Reparative Effects of Intestinal Trefoil Factor on Intestinal Mucosa

肠三叶因子(ITF)由杯状细胞合成和分泌,是肠道的特异性保护因子,通过与黏蛋白的结合、抑制免疫反应和调节凋亡来保护肠黏膜。ITF对维持肠黏膜的完整性、促进肠黏膜损伤后重建和修复具有重要作用。本文就ITF对肠黏膜保护与修复的研究作一综述。

Intestinal trefoil factor （ITF） is synthesized and secreted by goblet cells, and is a specific protective tactor of intestine. The protective effect on intestinal mucosa is through combining with mucin, inhibiting immune response and modulating cell apoptosis. ITF plays an important role in maintaining the integrity of intestinal mucosa, enhancing the reconstruction and repair after injury of intestinal mucosa. This article reviewed the study on protective and reparative effects of ITF on intestinal mucosa.