IgA肾病患者单核细胞趋化蛋白-1含量及其意义

The concentration of serum and urine monocyte chemoattractant protein-1 in patients with IgA nephropathy and its clinical significance

目的探讨IgA肾病患者血液、尿液中单核细胞趋化蛋白-1(MCP-1)的含量变化及其临床意义。方法选取20例8～18岁IgA肾病患者为实验组,20例健康体检者为对照组。用流式细胞仪检测两组血液中CD14+单核细胞的含量;采用酶联免疫吸附法(ELISA)检测血液、尿液MCP-1的含量,并进行比较。结果 IgA肾病患者血液中CD14+单核细胞的含量低于对照组,差异有统计学意义(P<0.01)。其尿液中MCP-1的含量较对照组明显增高,差异有统计学意义(P<0.01),而其血液MCP-1的含量与对照组比较差异无统计学意义(P>0.05)。结论 IgA肾病的发病与趋化因子MCP-1有关。监测尿液MCP-1的浓度可望作为临床上评价IgA肾病肾小管间质功能的一项无创伤性指标。

Objective To study the concentration of serum and urine monocyte chemoattractant protein-1 in patients with IgA nephropathy and its clinical significance.Methods Twenty patients with IgA nephropathy aged 8 to 18 years were enrolled as experimental group,while 20 healthy volunteers were enrolled as control group.The level of blood CD14＋ monocytes was measured by flow cytometery.The level of serum and urine MCP-1 were detected by ELISA.Results The level of blood CD14＋ monocytes in patients with IgA nephropathy was significantly lower than control group（P 0.01）.The urine concentration of MCP-1 in patients with IgA nephropathy significantly increased than control group（P 0.01）.There was no significant difference of the serum concentration of MCP-1 between patients with IgA nephropathy and control group.Conclusions The onset of IgA nephropathy was related with MCP-1.Monitoring urine concentration of MCP-1 is expected to serve as a non-invasive indicator to evaluate tubulointerstitial function of IgA nephropathy in clinical.