凝结芽孢杆菌活菌制剂在手足口病中的应用

Bacillus coagulans tablets in treatment of children with hand-foot-mouth disease

目的观察和评价凝结芽孢杆菌活菌制剂治疗手足口病的临床疗效。方法将64例手足口病患儿随机分为治疗组(31例)和对照组(33例),两组均给予对症支持治疗,其中治疗组同时加用凝结芽孢杆菌活菌片,≤1岁,0.70 g/次,>1岁,1.05 g/次,3次/d。对两组患儿的疱疹、食欲、体温等变化情况进行统计和分析。结果治疗组患儿疱疹好转、消失时间,食欲和体温恢复正常时间均显著短于对照组;痊愈率、总有效率高于对照组,差异均有统计学意义(P均<0.05)。结论凝结芽孢杆菌活菌片辅助治疗手足口病疗效显著。

Objective To observe the clinical efficacy of bacillus coagulans tablets in treatment of children with hand-foot-mouth disease.Methods Sixty-four children with hand-foot-mouth disease were randomly divided into two groups,treatment group（n = 31）and control group（n = 33）.All children received symptomatic treatment.In treatment group,Bacillus coagulans tablets was administered in doses of 0.70 g（under 1 year old）or 1.05 g（1 year old or older）three times a day.Results Compared to the control group,the healing time of herpes in treatment group was significantly reduced,the recovery time of appetite and temperature wsa also significantly shorter,and cure rate and total effective rate were significantly higher（all P 0.05）.Conclusions This study suggests that Bacillus coagulans tablets as a adjuvant theropy may have a beneficial effect in children with hand-foot-mouth disease.