摘要
IgM肾病系指以免疫荧光下肾小球系膜区IgM沉积为特征的原发性肾小球疾病。IgM肾病多数以肾病综合征起病,少数表现为蛋白尿、单纯血尿或蛋白尿合并血尿。光镜下肾小球可显现基本正常,也可有不同程度的系膜增殖。早期研究认为该病预后良好;目前研究提示,IgM肾病预后不容乐观,随访5～15年,其中7%～39%发展为肾功能不全,6%～36%进展为终末期肾病。因此,应将IgM肾病作为一独立疾病看待,并延长随访观察时间。
IgM nephropathy is a primary glomerulonephritis characterized by mesangial IgM deposition on immunofluorescence.The majority of IgM nephropathy patients presented with the onset of nephrotic syndrome,while others manifested as proteinuria or hematuira or both of them.Under light microscopic,the glomerulus may appear almost normal,or also have varying degrees of mesangial proliferation.Early studies considered IgM nephropathy as a disease with benign prognosis.However,current studies suggested that IgM nephropathy is a more severe disease.After five to fifteen years of follow up,7%-39% of the patients＇progress to renal insufficient and 6%-36% progress to the end stage renal disease.IgM nephropathy should be regarded as an independent entity and its follow up time should be prolonged.
出处
《临床儿科杂志》
CAS
CSCD
北大核心
2012年第4期389-392,共4页
Journal of Clinical Pediatrics
关键词
IGM肾病
肾病综合征
激素依赖
激素耐药
IgM沉积
IgM nephropathy
nephrotic syndrome
steroid dependence
steroid resistance
IgM deposition
