青少年慢性肾功能不全临床病理分析

Analysis on Clinicopathological Data of Adolescents with Chronic Renal Insufficiency

目的:总结青少年慢性肾功能不全(CRI)的病理类型分布及其临床特点。方法:回顾性分析71例CRI青少年患者的临床病理资料,探讨其临床特点及组织学变化。结果:71例患者中男女比例为1.22∶1,平均年龄(16.2±2.1)岁,Scr值135.8～521.3μmol/L。71例患者组织学类型多样,最常见的是IgA肾病,占36.62%,其次是狼疮性肾炎。肾小球全球硬化程度、肾小管萎缩程度和肾间质纤维化程度与Scr呈正相关。结论:青少年慢性肾功能不全的病理类型多样,应及早诊断,延缓慢性进展。

Objective：To investigate the relation between renal pathological category and clinical features in adolescents with chronic renal insufficiency.Methods：71 adolescents with CRI admitted to Tianjin MedicaI University General Hospital from 2000 to 2011 were systematically reviewed,including demographic data,clinical features,laboratory findings.Results：Gender composition 1.22：1,age at the diagnosis is（16.2±2.1）years.Scr ranged from 135.8 to 521.3 μmol/L.IgA nephropathy accounted for 36.62% of the total patients.elevated Scr correlated with glomerular sclerosis and renal tubul atrophy,renal interstitial fibrosis chronic changes.Conclusion：The histological classification of renal biopsy is multiple of adolescents.and it should make a correct diagnosis at the early stage,so that delay chronic progress.