左卡尼汀对预防奥沙利铂周围神经毒性作用的临床观察

Clinical observation of levocarnitine in prevention from peripheral nerve toxicity caused by oxaliplatin

目的观察左卡尼汀对奥沙利铂引起的周围神经毒性反应的预防性治疗作用。方法 70例接受奥沙利铂化疗的肿瘤患者随机分为两组,预防性治疗组患者在应用奥沙利铂化疗同时给予左卡尼汀治疗,对照组化疗方案与前组相同但未接受左卡尼汀预防性治疗。分别比较两组患者的神经毒性总发生率、外周感觉神经毒性级别、出现外周神经毒性时间及肿瘤相关性疲劳分级和体力状况评分。结果预防性治疗组神经毒性发生率、外周感觉神经毒性级别均低于对照组,且差异有统计学意义(P<0.05)。结论应用奥沙利铂联合化疗中预防性给予左卡尼汀,可减少化疗相关的神经毒性,值得进一步研究。

Objective To observe levocarnitine in prevention and treatment of peripheral nerve toxicity caused by oxaliplatin. Methods Tatal 70 cancer patients treated with oxaliplatin-based chemotherapy were randomly divided into two groups, the preventive treatment group and control group. The patients in the preventive treatment group were treated with oxaliplatin chemotherapy and at the same time were administered with levocarnitine. The patients in the control group were treated with the same chemotherapy regimen but without levocarnitine. The incidence rate of neurotoxicity, the level of peripheral sensory nerve toxicity, the appeared time of peripheral neurotoxicity appeared, the level of cancer-related fatigue and the physical status score between two groups were compared respectively. Results The incidence rate of neurotoxicity and the level of peripheral sensory nerve toxicity in the preventive treatment group were lower than that of the control group （P〈0.05）. Conclusion Application of levocarnitine in oxaliplatin-based chemotherapy can reduce the neurotoxicity caused by chemotherapy.