青蒿琥酯静脉注射7天疗程治疗恶性疟疗效观察

Treatment of Falciparum Malaria with Intravenous Injection of Artesunate for 7 Days

青蒿琥酯注射剂治疗恶性疟以及凶险型疟疾的推荐剂量为3天疗程,总量240mg。该剂量具有速效、低毒的优点,但原虫复燃率高达50%左右.试用7天疗程,总量480mg方案治疗恶性疟40例,原虫复燃率降至5.6%,亦未见毒副反应。本文结果提示,适当延长青蒿琥酯注射剂的疗程和增加总剂量,可明显地降低疟原虫的复燃率;延长疗程、增加总剂量而不增加每天量,未见毒副作用出现。

A total dose of 240 mg (4.8mg/kg) Artesunate in 3 days was used to treat 173 adult patients with falciparum malaria. The mean time for fever subsidence was 16.1±8.3 hrs, and for asexual parasite clearance, 56.5±14.9 hrs. The recrudescence rate after 28 days was 49.4％. When they were examined at the first, the third and the sixth days after treatment, there were no obvious abnormal changes in 50 patients in such tests as hemocrit, urinalysis, SGPT, SGOT, AKP, creatinine, bilirubin EKG, etc. It was also found that there were no hemolysis response in 5 patients with G-6-PD deficiency disease.