急性心肌梗死发病早期的血脂异常

Lipid changes in early stage of acute myocardial infarction

目的 探讨急性心肌梗死 (AMI)患者发病 2 4h之内的血脂水平及与年龄、性别、吸烟、高血压病、糖尿病的关系。方法 对 12 0例AMI患者入院时的总胆固醇 (TC)、低密度脂蛋白 胆固醇(LDL C)、高密度脂蛋白 胆固醇 (HDL C)、血清甘油三酯 (TG)进行测定 ,并根据患者年龄、性别 ,是否吸烟、有无合并糖尿病、高血压病进行分组 ,比较各组间的血脂。结果 急性心肌梗死发病 2 4小时之内TC >5 72mmol/L和 /或LDL C >3 6 4mmol/L者占 31 6 7% ,TC在 (4 6 8～ 5 72 )mmol/L和 (或 )LDL C(2 6 0～ 3 6 4)mmol/L之间者占 48 33% ;单纯TG >1 70mmol/L者 5例 ,单纯HDL C <0 91mmol/L者 3例 ,单纯高TG合并低HDL C者占 2例 (TC及LDL C正常 ) ;总计为 78 33%。结论 在急性心肌梗死发病 2 4h之内 ,可以发现血脂异常。在男性和女性、高血压病和非高血压病、糖尿病和非糖尿病、吸烟组和非吸烟组患者之间血脂差异有显著性。

Objective The purpose of this investigation was to discover the serum lipid level on the morning in early stage (≤24 hours) of acute myocardial infarction (AMI) and its relationships with age, gender, smoking,diabetic mellitus (DM), hypertension Methods Plasma cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL C), high density lipoprotein cholesterol (HDL C),were measured in 120 patients with proven acute myocardial infarction (occurred≤24 hours) Results TC level in 31 67% of patients the more than 5 72 mmol/L and/or LDL C>3 64 mmol/L In 38 33% of patients the TC level was (4 68～5 72) mmol/L and/or LDL C level (2 60～3 64) mmol/L In five patients the TC level were >1 70 mmol/L (singleness) In three patients the HDL C level were <0 91 mmol/L (singleness) Two patients were the TC level >1 70 mmol/L and the HDL C level <0 91 mmol/L (TC and LDL C normal) In 78 33% of patients was serum lipid disorders Conclusion Serum lipid disorders can be detected in early stage of acute myocardial infarction Lipid levels of patients were different between men and women, diabetic mellitus and non diabetic mellitus, hypertension and non hypertension, smoking and non smoking