检测肺癌患者血清中肝细胞生长因子 血管内皮生长因子含量的临床意义

Clinical significance of detecting serum level of VEGF and HGF in patients with lung cancer

目的探讨血清中肝细胞生长因子(HGF)、血管内皮生长因子(VEGF)含量对肺癌的影响,及其各自在判断肺癌种类方面的价值。方法收集40例肺癌患者,12例肺良性病变患者,15例健康对照组人群的血清。采用酶联免疫吸附试验(ELISA)分别测定HGF、VEGF的含量。结果肺良性病变、健康对照组血清中HGF分别为(245±135)、(228±164)ng/L,无明显升高,VEGF分别为(65±32)、(59±28)ng/L,肺癌组HGF[(431±202)ng/L]、VEGF[(165±52)ng/L]均分别高于肺良性病变组及健康对照组,差异有统计学意义(P<0.01)。两种血管生长因子在不同类型肺癌中的阳性表达比较分析显示,HGF以肺腺癌中表达更明显,VEGF在肺鳞癌患者血清升高更明显(P<0.01)。结论肺癌患者血清中HGF、VEGF升高,联合检测对肺癌的诊断和鉴别诊断具有重要价值,有望为提高肺癌的早期检出率提供新的依据。

Objective To investigate the influence of serum vascular endothelial growth factor(VEGF) and hepatocyte growth factor(HGF) in lung cancer patients. Methods The levels of VEGF and HGF in 40 patients with lung cancer,12 patients with lung benign diseases and 20 healthy persons as control group were detected by ELISA.Results The serum levels of HGF and VEGF were(245±135) and(65±32)ng/L in the lung benign diseases group and(228±164) and(59±28) ng/L in the healthy control group.The serum levels of HGF and VEGF were(431±202) ng/L and(165±52)ng/L respectively and significantly higher than those in lung benign diseases group and the healthy control group with statistical difference(P<0.01).The comparative analysis on the positive expression of two growth factors in different lung cancers showed that the expression of HGF in lung adenocarcinoma was more obvious and the serum level of VEGF were increased more significantly in lung squamous carcinoma.Conclusion Serum VEGF and HGF are increased in the patients with lung cancer.The combination detection of VEGF and HGF has important value to the diagnosis and differential diagnosis of lung cancer and is expected to provide new evidence for increasing the early detection rate of lung cancer.