长期住院精神分裂症患者凝血指标检测分析及临床意义

Coagulation testing analysis and its clinical significance in long-term hospitalized schizophrenic patients

目的探讨凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)和纤维蛋白原(FIB)检测在判断长期住院精神分裂症患者凝血功能状况、出血危险性及治疗预后方面的临床价值。方法采用Sysmex CA 50血凝分析仪对87例患者和79例健康对照者进行凝血4项指标检测。结果精神分裂症患者治疗前凝血4项指标检测与健康对照组比较差异无统计学意义(P>0.05);治疗后PT、APTT、TT延长,分别为(21.6±5.3)s、(50.8±20.1)s、(23.3±4.9)s,FIB减少[(1.14±0.61)g/L],与健康对照组比较差异有统计学意义(P<0.05)。结论长期使用抗精神病药物对精神分裂症患者的肝功能有一定损害,临床在治疗过程中通过定期监测患者的凝血指标,有利于精神分裂症患者的康复及预后评估。

Objective To investigate the clinical value of prothrombin time（PT）,activated partial thromboplastin time（APTT）,thrombin time（TT） and fibrinogen（FIB） detections to judge the coagulation status,bleeding risk,treatment and prognosis in the long-term hospitalized schizophrenic patients.Methods The 4 coagulation indicators in 87 patients and 79 healthy controls were detected by Sysmex CA 50 blood coagulation analyzer.Results Four indicators of coagulation test before treatment in schizophrenia patients had no statistical difference compared with the healthy control group（P0.05）.After treatment,PT,APTT and TT were prolonged and（21.6±5.3）s,（50.8±20.1）s and（23.3±4.9）s respectively,FIB was decreased [（1.14±0.61）g/L）],showing statistical difference（P0.05）.Conclusion Long-term use of antipsychotic drugs has certain damage on liver function in the patients with schizophrenia.During the clinical treatment course in schizophrenic patients,regular monitoring the coagulation indicators for understanding drug-induced liver function damage is conducive to the rehabilitation and prognosis of schizophrenic patients.