熊去氧胆酸对胆汁淤积型婴儿肝炎综合征胆汁酸代谢的影响

The Effects of Ursodeoxycholic Acid on Bile Acid Metabolism in Cholestatic Infantile Hepatitis Syndrome Province 430000

目的:探讨熊去氧胆酸(UDCA)对婴儿肝炎综合征(IHS)胆汁酸代谢的影响。方法:82例IHS患儿随机分为治疗组42例与对照组40例,两组病例均予保肝及综合治疗。治疗组在此基础上加用UDCA 20mg/(kg.d),分2次服用,连续应用10～15d为1个疗程。治疗2周后观察患儿血清总胆汁酸(TBA)、总胆红素(TBIL)、γ-谷氨酰基转移酶(GGT)等,判断药物疗效。结果:疗程结束后加用熊去氧胆酸治疗组TBA、TBIL、GGT下降明显,优于对照组(P<0.05);治疗组和对照组总有效率分别为95.2%和80.0%,治疗组优于对照组(P<0.05)。结论:熊去氧胆酸治疗婴儿肝炎综合征,可促进胆汁酸排泄、加速黄疸消退,安全有效。

Objective： Explore ursodeoxycholic acid（UDCA） on bile acid metabolism in cholestatic infantile h,betitis syndrome （IHS）. Methods： 82 cases of IHS were randomly divided into treatment group （n=42） with the control group of 40 cases, two groups of patients herein are hepatoprotective and comprehensive treatment. Treatment group on this basis,plus UDCA 20mg/（kg · d）, divided into two doses, continuous application of 10-15days for a course. After 2 weeks of treatment, serum total bile acid （TBA）, total bilirubin （TBIL）,glutamyl transpepti-dase （GGT）, to deter- mine drug efficacy. Results： UDCA treatment group after treatment of TBA, TBIL, GGT in significantly decreased, than the control group（P.〈0. 05） ; treatment group, control group in serum were 95. 2% and 80.0%. Treatment group bet- ter than the control group （P〈0. 05）. Conclusion： UDCA treatment of IHS promote bile acid excretion, accelerated jaundice, safe and effective.