抗高血压药物的门诊处方分析

Analysis of Outpatient Prescriptions of Antihypertensive Drugs

目的:了解和分析我院门诊抗高血压药的应用状况,为临床合理用药提供参考。方法:将2011年6-9月3 486例门诊高血压患者处方进行统计分析,包括年龄和性别差异对高血压的影响、联合用药情况,采用WHO推荐的限定日剂量分析方法分析抗高血压药的临床使用情况。结果:各年龄组间的高血压患病率存在显著性差异,其随年龄的增长而显著增加。钙离子通道拮抗药(CCB)、血管紧张素转换酶抑制剂(ACEI)和血管紧张素Ⅱ受体拮抗剂(ARB)的使用频率最高。联合用药占全部处方的24.07%,其中以二联用药为主。结论:我院抗高血压药应用基本符合2010年版《中国高血压防治指南》,单药治疗以第3代钙通道拮抗药和长效ACEI为主。大部分联合用药方案较合理,但也存在一些重复用药行为,须引起重视。

Objective：To understand and analyze the application of antihypertensive drugs in out-patients of our hospi- tal, and to provide reference for clinic drug use. Methods： The prescriptions of 3 486 out-patients with hypertension from June to September in 2011 were written out. The influence of age and sex on the cost,kind of drug used and combined drug use were analyzed,and defined daily dose recommended by WHO. Results： The differences between different age groups in respect of incidences of hypertension were significant and increased with the increase of age. The most fre- quently prescribed antihypertensive drugs were calcium channel blocker, β-receptor blocker and angiotensin converting enzyme inhibitor（ACEl）. The rate of drug combination accounted for 24. 07 % of the total prescriptionS, most of which were combination of two drugs. Conclusion..The utilization of antihypertensive drugs in our hospital of TCM was basi- cally in line with China Guidelines on Prevention and Management of High Blood Pressure The third generation calci- um channel blocker and ACEI with prolonged action took the lead among the monotherapy. Most of the drug combina- tion therapies were rational, but there were cases of repeated use of drugs, which call for great attention in the clinic.