艾司西酞普兰联合阿立哌唑治疗强迫症46例

Escitalopram combined with aripiprazole in the treatment of 46 patients with obsessive compulsive disorder

目的探讨艾司西酞普兰与阿立哌唑联合治疗强迫症临床效果及安全性。方法强迫症患者97例，随机分为两组，其中对照组5l例，采用艾司西酞普兰口服治疗，观察组46例，在上述基础上加用阿立哌唑121服治疗；治疗结束后评价临床疗效及不良反应发生情况。结果观察组患者治疗总有效率为89．1％明显优于对照组68．6％（X^2=12．32，P〈0．05）；观察组患者治疗后Y—BOCS评分（21．82±2．88）分亦明显优于对照组患者的（23．68±2．74）分（t=2．64，P〈0．05）；而两组患者治疗结束后TESS评分及不良反应发生率均差异无统计学意义（t=0．61；X^2=0．03，均P〉0．05）。结论艾司西酞普兰联合阿立哌唑治疗强迫症临床效果显著，且不良反应少，具有临床推广使用价值。

Objective To observe and explore the clinical efficacy and safety of escitalopram combined with aripiprazole in the treatment of obsessive-compulsive disorder. Methods 97 patients with obsessive-compulsive disorder were randomly divided into two groups ,control group of 51 patients were given oral administration of escitalopram treatment,46 patients in the experimental group received escitalopram and oral aripiprazole treatment. At the end of treatment, the clinical efficacy and adverse events were evaluated. Results In control group and experimental group patients overall effective rate was 68.6% ,89.1% ;The experimental group the total effective rate was higher than the control group, the difference between two groups was statistically significant （ X^2 = 12.32, P 〈 0.05 ）, The control group and experimental group after treatment Y-BOCS scores were （23.68 ± 2.74） points, （21.82 ± 2.88 ） points ; The exper- imental group after treatment Y-BOCS score was significantly better than the control group, between the two groups the difference was statistically significant （ t = 2.64, P 〈 0.05 ） ; While after treatment the TESS.score and incidence of ad- verse reactions between the two groups were not statistically different （ t = 0. 61 ; X2 = 0. 03, all P 〉 0. 05 ）. Conclusion Escitalopram combined with aripiprazole in the treatment of obsessive compulsive disorder obtain excellent effect, had few adverse reactions, and was worthy of clinical application.