转化生长因子-β1和血管内皮生长因子在鼻腔鼻窦内翻转乳头状瘤组织中的表达

Clinical significance of TGF-β1 and VEGF expression in tissues of nasal inverted papilloma

目的探讨转化生长因子-β1（TGF—β1）和血管内皮生长因子（VEGF）在鼻腔鼻窦内翻转乳头状瘤（NIP）组织的中作用。方法采用免疫组织化学法测定100例NIP患者手术切除的NIP组织和鼻息肉组织中TGF．61和VEGF的表达。并按病理诊断结果将100例NIP患者分为良性病变组、不典型增生组、恶变组，鼻息肉组为对照组。结果NIP组TGF—β1和VEGF阳性表达率分别为46．0％和32．0％，均显著高于对照组（均P〈0．05）。在不同病理类型组中，TGF—β1和VEGF阳性表达率为：恶变组〉不典型增生组〉良性病变组（P〈0．05）。NIP中TGF-β1和VEGF阳性表达呈显著正相关性（P〈0．05）。结论GF—β1和VEGF与NIP的发生、发展和恶变密切相关。TGF—β1在NIP组织中高表达，并通过上调VEGF的表达而促进NIP新生血管的形成。

Objective To investigate the clinieal significance of transforming growth factor β1（TGF-β1） and vascular endothelial growth factor （VEGF） expression in tissues of nasal inverted papilloma （NIP）. Methods The clinical data of patients with NIP underwent surgical resection were retrospectively analyzed. The TGF-β1 and VEGF expression in NIP tissues and nasal polyps tissues were detected by immunohistoehemistry meth- od. 100 patients with NIP were divided into benign lesions, atypical hyperplasia and malignant group according to result of pathological diagnosis, the nasal polyps was used as the control group. Results The positive expression rate of TGF-β1 and VEGF in the NIP group were 46.0% and 32.0%, compared with the control group the differences were significant（all P 〈0.05）. In different pathological groups, the results of TGF-β1 and VEGF expression were malignant group 〉 atypical hyperplasia 〉 benign lesions. The positive expression rate of TGF-β1 and VEGF in the NIP group had significantly positive correlation（ P 〈 0.05 ）. Conclusion The TGF-β1 and VEGF expression were closely related to the the oeeurrenee, development and malignant of NIP. TGF-β1 was highly expressed in the NIP tissues, and could increase the expression of VEGF and promote the formation of neovaseularization of NIP.