含铜IUD、小剂量米非司酮与单方左炔诺孕酮用于紧急避孕的临床比较观察

A Clinical Comparative Observation among Copper IUD、 Lower Dose Mifepristone and Levonoregestrel for Emergency Contraception

为观察米非司酮 (Ru4 86)、左炔诺孕酮以及活性IUD用于紧急避孕 (EC)的临床效果、副反应、对月经的影响和活性IUD的长期避孕效果 ,对 150例身体健康、月经规律、未避孕或避孕失败 12 0h以内的妇女按自愿的方式分为放置IUD组或服药组 ,服药组按随机方法给予口服Ru4 86或左炔诺孕酮。结果发现Ru4 86组和活性IUD组有效率为 10 0 % ,左炔诺孕酮组为 76 8% (均按Dixon方法计算 ) ,对月经的影响及副反应的发生率很低。说明 :此三种EC方法均安全有效 ,活性IUD不引起生殖系统感染 ,可以作为一种长期避孕措施继续应用。

The efficacy,side-reaction of copper IUD,mifepristone and levonorgestrel in emergency contraception were studied,and the influence of these contraceptive devices on menstruation was also observed.150 cases healthy women were given with oral Ru486(10mg),copper intrauterine device(IUD) or levonorgestrel (0.75mg taken in two equal doses 12 hours apart) respectively,after sexual intercourse within 120 hours without contraception or failed contraception.The results showed that the effective rates of Ru486 and copper IUD for emergency contraception were both 100%,while the levonorgestrel group was 76.88%(Calculation with Dixon method).The influence of the emergency contraception on both menstruation and the side reaction were light.The data suggest that the three methods for emergency contraception were high efficacy,safety.The copper IUD insertion has no complications and can be used for up to 10 years.