摘要
目的 检测Notch1受体在颌骨成釉细胞瘤中的表达,探讨Notch1信号途径在颌骨成釉细胞瘤发生中的作用.方法 采用免疫组化方法检测69例颌骨成釉细胞瘤Notch1受体的表达.结果 所有颌骨成釉细胞瘤标本中均有Notch1受体的表达,阳性染色位于细胞膜和细胞质.高表达的Notch1受体主要分布在外周柱状或立方状肿瘤细胞中,而在中央多角形肿瘤细胞中Notch1受体低表达.结论 Notch1受体在颌骨成釉细胞瘤中广泛表达,其表达方式提示Notch 1信号途径可能通过调控肿瘤性牙源性上皮的增殖和分化,从而在颌骨成釉细胞瘤的发生中起作用.
Objective To investigate the expression of Notch1 receptor in ameloblastoma of the jaw and its significance. Methods The expression of Notch1 receptor was detected by immunohistochemistry in tissue specimens from 69 patients with ameloblastomas of the jaw. Results Notch1 receptor was expressed in all specimens and immunostaining was located in cel- lular membrane and cytoplasm. High expression of Notch1 receptor was mainly distributed in peripheral columnar or cuboidal neoplastic cells. A low level of Notch1 receptor was observed in central polyhedral neoplastic cells. Conclusion Notch1 receptor is unequivocally expressed in ameloblastoma of the jaw, suggesting that Notch1 signaling pathway might be associated with proliferation and differentiation of neoplastic odontogenic epithelium, and involving in the tumorigenesis of ameloblastoma.
出处
《浙江医学》
CAS
2012年第6期435-437,共3页
Zhejiang Medical Journal
基金
浙江省自然科学基金项目（Y206192）
