接触性皮炎斑贴试验标准系列抗原的对比研究

A comparative study of standard aptch testing series of contact dermatitis

目的 :比较自制抗原 (简称自抗 )与欧洲标准系列抗原 (简称欧抗 )质量并评估欧洲标准系列抗原在我国临床应用的可行性。方法 :按照国际接触性皮炎研究组 ICDRG(InternationalContact Dermatitis Research Group)提供的抗原标准 ,用国产试剂配制抗原。通过实验室检测、动物试验和临床应用来评价抗原质量。通过对接触性皮炎病人的检测 ,观察阳性率的的高低以评估在临床应用的可行性。结果 :自抗在实验室检测、动物皮肤刺激试验及临床应用与欧抗比较均无显著性差异 ,欧抗斑试总阳性率为 37.65% ,其中阳性率在 1 %以上的抗原为 1 1种。提示这些抗原也为天津常见的致敏原。结论 :自抗质量达到欧抗水平 ;

Objective:To compare the quality of our domestic allergens with European standard series and to estimate the possibility of clinical application in China Methods: Domestic allergens were prepared according to the criterion provided by the International Contact Dermatitis Research Group (ICDRG) The quality of domestic allergens estimated by laboratory examinations, animal tests and clinical application The possibility of clinical application evaluated by the patch testing positive rate to the contact dermatitis patientsResults:No significant differences between domestic allergens and European standard series allergens in laboratory examinations, animal tests and clinical application The total patch testing positive rate of European standard series was 3765%, in which, positive rate of 11 kinds allergens were more than 1%, it indicated that this allergens were also common allergens in TianjinConclusion: Our domestic allergens reach the quality level of European standard series; European standard series allergens are also suitable for our country's clinical application