基质金属蛋白酶-9及白细胞介素-6对颈动脉粥样硬化斑块易损性的影响

The effect of serum MMP-9 and IL-6 on the vulnerability of carotid atherosclerotic plaque

目的探讨MMP-9及IL-6与人颈动脉粥样硬化斑块易损性的关系。方法选择急性脑梗死患者69例和健康对照者20例,根据粥样硬化斑块性质分为易损性斑块组和非易损性斑块组,比较两组患者血清MMP-9和IL-6水平,并对二者间关系进行相关分析。结果非易损性斑块组患者血清MMP-9和IL-6表达水平高于正常对照组(均P=0.000),易损性斑块组表达水平高于非易损性斑块组和正常对照组(均P=0.000),MMP-9和IL-6在外周血中的表达变化与斑块易损性呈正相关关系(r=0.836,P=0.043)。结论血清MMP-9和IL-6是促进颈动脉粥样硬化斑块易损的重要因素,IL-6可上调MMP-9的表达水平。

Objective To explore the relationship of MMP-9 and IL-6 and the vulnerability of earotid atherosclerotie plaque. Methods According to the plaque vulnerability, 69 patients with acute cerebral infarction were divided into vulnerable plaque group （n = 35） and unvulnerable plaque group （n = 34）. Twenty healthy subjects were selected as controls （control group）. The levels of serum IL-6 and MMP- 9 were examined. Results The level of MMP- 9 and IL- 6 in the unvulnerable plaque group was significantly higher than that in control group （P = 0.000, for all）. The level of MMP-9 and IL-6 in the vulnerable plaque group was higher than that in the unvulnerable plaque group and control group （P= 0.000, for all）. A positive correlation was observed between the expression of MMP-9 and IL-6 plaque （r = 0.836, P = 0.043）. Conclusion MMP-9 and IL-6 are important factors for the promotion of vulnerable plaque. IL-6 may up-regulate the expression of MMP-9.