一例来京就诊脊髓灰质炎疫苗病毒高变异株病例的流行病学调查与分析

Epidemiological survey of case caused by highly variant vaccine derived poliovirus in Beijing

目的阐述1例来北京市就诊的脊髓灰质炎(脊灰)疫苗病毒高变异株病例的流行病学调查与分析。方法对疫情开展病例个案调查、排毒监测、病毒传播的风险评估,参考《高危和聚集性AFP病例调查指南》要求,对病例进行消毒和隔离。结果 2010年7月,北京市从1例江西省来京就诊的急性弛缓性麻痹病例中分离到脊灰病毒,经国家脊灰实验室核苷酸序列测定为Ⅲ型脊灰疫苗病毒高变异株。患儿曾在原籍口服一剂脊灰减毒活疫苗(OPV),但接种过程不规范。结论该病例最终经专家小组分类诊断为疫苗相关麻痹型脊灰病例,通过采取相关措施,最终控制了疫情的蔓延。

Objective To understand the epidemiological characteristics of a case caused by highly variant vaccine-derived poliovirus in Beijing.Methods The case survey,virus excretion monitoring and transmission risk assessment were conducted and the case was isolated according to ＂Survey guideline of high risk and clustering AFP cases＂.Results In July 2010,polio virus was isolated from a AFP case from Jiangxi province to Beijing for medical care seeking,the isolate was identified as highly variant vaccine derived poliovirus type Ⅲ by nucleotide sequencing in state polio laboratory.The case had received irregular 1 dose OPV immunization.Conclusion The case was finally diagnosed with vaccine-associated paralytic poliomyelitis（VAPP） and no further transmission occurred due to strict prevention and control measures.