人脑胶质瘤组织内微血管定量的临床意义

Clinical Significance of Microvessel Quantitation in Human Gliomas

目的 :探讨人脑胶质细胞瘤组织内微血管定量 (MVQ)的临床意义。方法 :应用免疫组织化学技术在63例人脑胶质瘤组织中对第Ⅷ因子相关抗原进行表达 ,并计数肿瘤MVQ。结果 :Ⅲ、Ⅳ级胶质瘤MVQ显著高于Ⅰ、Ⅱ级(P<0.05) ;术后18个月内复发和生存期<3年者MVQ分别高于术后18个月无复发及生存期>3年者 (P<0.01) ;MVQ与患者性别、年龄、肿瘤生长部位无明显相关 (P>0.05)。结论 :人脑胶质瘤MVQ与病理分级、术后复发及生存期关系密切 。

Obvjective: To study the clinical significance of microvessel quantitation (MVQ) in human gliomas. Methode: MVQ were highlighted for factor Ⅷ related antigen by means of immunostaining the endothelial cells in 63 tissue specimens of human glioma. Results: MVQ in gliomas of grade Ⅲ, IV was significantly higher than those in grade Ⅰ, Ⅱ (P< 0.05). MVQ in the patients who had relapse within 18 months postoperatively or survived shorter than 3 years was higher than those without recurrence within 18 months or survived longer than 3 years (P< 0.01). MVQ was not related with the patient's sex, age and the site of tumor (P >0.05). Conclusion: It is suggested that MVQ corelates positively to histological grade, postoperative recurrence and survival period in human glioma and that it would be a significant predicting index of prognosis