肝硬化合并多器官功能衰竭98例临床分析

Clinical Analysis of Cirrhosis Complicated with Multiple Organ Failure(MOF) in 98 Cases

目的对肝硬化并发多器官功能衰竭(MOF)的特点进行临床分析,以探讨更好的防治措施。方法根据病史、症状、体征,实验室检查及B超、CT、内镜等辅助检查结果,对98例肝硬化合并多器官功能衰竭患者进行回顾性分析。结果 98例MOF患者中死亡40例(40.8%),无MOF者257例,共死亡12例(4.67%),两组病死率相比较差异有显著性(P<0.01)。98例MOF中2个器官衰竭76例,死亡18例(24%),3、4个器官衰竭22例全部死亡;两者病死率有明显差异(P<0.01)。结论肝硬化合并MOF并非少见,病死率随受累脏器数目的增加而增加。早期诊断,早期预防是提高救治成功率,降低死亡率的关键。

Objective To explore the diagnosis,prevention and treatment of cirrhosis complicated with multiple organ failure（MOF） through the clinical analysis of its characteristics.Methods 98 cases of cirrhosis complicated with MOF were analyzed retrospectively including the patients＇ medical history,symptoms and signs,the results of laboratory findings and auxiliary examinations such as B ultrasound,CT and endoscope.Results 40 patients were dead in 98 cases of MOF（40.8%）,while 12 patients were dead in 257 cases without MOF（4.67%）;the difference of mortality between two groups had statistical significance（P〈0.01）.In 98 cases of MOF,76 cases had 2 organ failures with 18 cases of death（24%）,22 cases had 3 or 4 organ failures and all cases were dead;the difference of mortality between them had statistical significance（P〈0.01）.Conclusions Cirrhosis complicated with MOF is not rare and the mortality rate rises along with the increase of failured organs.Early diagnosis and prevention is the key to improve the success rate of treatment and reduce the mortality.