乳腺癌患者MRP基因表达及临床意义

MRP Expression in Primary Breast Carcinoma and Its Clinical Significance

目的 :检测MRP基因在人乳腺癌组织中的表达状况 ,初步分析其临床意义。方法 :37例待手术乳腺癌患者随机分为直接手术、术前化疗、术前化疗加三苯氧胺三组。采用RT -PCR法检测癌组织中MRP基因表达。结果 :术前化疗组MRP阳性率28.6 %(6/21) ;直接手术组MRP极弱或无表达(0/8) ;(P<0.01) ;加用三苯氧胺MRP表达减少为1/8。局部晚期病例MRP基因表达多呈阳性(5/9)。结论 :以上结果提示MRP是乳腺癌MDR产生的机制之一 ;MRP基因表达与乳腺癌的发展有关 。

Purpose: This research is to investigate the expression of multidrug resistance associated protein (MRP)in primary breast carcinoma and to evaluate its clinical signification. Methode: The expression of MRP in 37 cases of breast carcinoma were assayed by RT-PCR. Eight patients were not treated with chemotherapy before operation, 21 patients were treated with chemotherapy, the other 8 patients were treated by chemotherapy plus Tamoxifen. Results: The expression of MRP in patients treated with chemotherapy was higher (6/21) than that of untreated patients (0/8), P< 0.01. The overexpression of MRP appeared in most patients who had local advanced breast cancer (5/9), P< 0.05. Conclusion: These results suggest that MRP gene expression in breast cancer is most likely induced by chemotherapy and that it is associated with progress of breast cancer.