肺癌、食管癌胸膜腔冲洗液细胞学检查的临床意义

Clinical Significance of Pleural Lavage Cytology in Patientswith Bronchogenic and Esophageal Carcinomas

目的 :明确胸膜腔冲洗液细胞学检查(PleuralLavageCytology ,PLC)在肺癌、食管癌外科临床中的意义。方法 :对32例肺癌和30例食管癌手术患者开胸后用200ml生理盐水冲洗胸腔并作细胞学检查。结果 :肺癌和食管癌PLC阳性率分别为15.6 %和20 %。PLC阳性率与患者性别 ,年龄 ,临床症状 ,病程 ,组织学类型 ,T、N分级及TNM分期等因素均无相关性 ,与食管癌病灶部位及病灶长度也无相关性。结论 :PLC可作为肺癌 ,食管癌的一个辅助分期和预后因素 。

Objective:To evaluate the clinical significance of pleural lavage cytology in patients with bronchiogenic and esophageal carcinoma without pleural effusion. Methode: We conducted a prospective study on 81 patients undergoing thoracotomy in our department comprising 32 cases of bronchiogenic carcinoma,30 cases of esophageal carcinoma and 19 cases of other lesions. Results: A positive lavage cytology of 15.6% and 20% were found in patients with bronchiogenic and esophageal carcinomas respectively.There were no significant correlation with gender,age,clinical symptoms,histology,T or N grade,TNM stage and tumor locations. Conclusion: The incidence of positive pleural lavage cytology in patients with bronchiogenic and esophageal carcinoma is disconcertingly high,and positive cytology may be a prognosticator of a more aggressive tumor biology, and should be added to the pTNM classification when assessing the final tumor stage.