癌灶内小静脉侵袭程度预测直肠癌肝转移的意义

Forecasting of Hepatic Metastasis of Colorectal Cancer by the Invasion of Intracancerous Venules

目的 :明确直肠癌癌灶内静脉侵袭同肝转移的关系 ,探明癌灶内静脉侵袭对直肠癌肝转移的预测作用。方法 :随机选取本院1992年5月至1993年6月 ,54例直肠癌病例 ,取其手术切除标本 ,采用抗第Ⅷ因子免疫组织化学染色 ,对癌灶内的静脉侵袭加以判定 ,继之探讨静脉侵袭同肝转移的关系。本组肝转移病例包括术中探明的同时性肝转移4例及术后5年随访复查的异时性肝转移5例。结果 :静脉侵袭阳性V( +)组肝转移率为30.77 % ,静脉侵袭阴性组V( -)肝转移率为3.57 % ,两组间有极显著差异 ( χ2=7.18,P<0.01)。结论 :癌灶内的静脉侵袭同肝转移密切相关 ,静脉侵袭可作为预测肝转移的指标 ,对V( +)

Aim: To correlate invasion of intracancerous venules with liver metastasis of colorectal cancer. Methode: 54 operative specimens of resected colorectal cancers in this hospital from May 1992 to June 1993 were studied by anti-factor Ⅷ immunohistochemistry for invasion of tumor venules.Four cases of liver metastasis were found during operation ,and 4 cases in the following 5 years. Results: The rate of liver metastasis was 30.77% of the cases with intracancerous venular involvement, and was only 3.57% in cases no venule invasion was found. The significant difference was observed between these two groups (χ2=7.18, P< 0.01). Conclusion: Intracancerous venular invasion in colorectal cancer is closely related with liver metastasis, and this finding may be an index marker for predicting liver metastasis of colorectal cancer.