SOCS2和STAT3蛋白的表达及其与胃癌生物学行为的关系

Relationship between expression of SOCS2 and STAT3 and biologic behaviors of gastric carcinoma

目的:探讨SOCS2和STAT3蛋白在胃癌组织中的表达及其与胃癌生物学行为的关系.方法:应用免疫组织化学方法检测55例胃癌组织和55例正常胃组织中SOCS2和STAT3蛋白的表达情况,并分析二者与胃癌分化程度、淋巴结转移、浸润深度和临床分期及患者性别、年龄之间的关系,同时分析二者的相关性.结果:SOCS2在胃癌组织中的阳性表达率为25.5%,明显低于正常胃组织中的91.1%(P<0.05),且表达与分化程度、淋巴结转移、临床分期相关(P<0.05);STAT3在胃癌组织中的阳性表达率为72.7%,明显高于正常组织的18.2%(P<0.05),且表达与分化程度、淋巴结转移、浸润深度和临床分期相关(P<0.05),SOCS2与STAT3的表达呈负相关(r=-0.486,P<0.01).结论:SOCS2在胃癌组织中低表达,STAT3异常活化可促进细胞的过度增殖,促进胃癌的发展,二者的相互调节在胃癌发生发展中起重要作用.

AIM： To investigate the relationship between expression of suppressor of cytokine signaling 2 （SOCS2） and signal transducer and activator of transcription 3 （STAT3） and biological behaviors of gastric carcinoma. METHODS： The expression of SOCS2 and STAT3 in 55 cases of gastric carcinoma and 55 cases of normal gastric tissue was detected by immunohistochemistry. The correlation of SOCS2 and STAT3 expression with tumor differentiation grade, lymph node metastasis, depth of invasion, clinical stage and patients＇ gender and age was analyzed. RESULTS： The positive rate of SOCS2 expression in gastric carcinoma was significantly lower than that in normal gastric tissues （25.5% vs 91.1%, P 0.05）. SOCS2 expression in gastric carcinoma was significantly associated with tumor differentiation grade, lymph node metastasis and clinical stage （all P 0.05）. The positive rate of STAT3 expression in gastric carcinoma was significantly higher than that in normal gastric tissue （72.7% vs 18.2%, P 0.05）. STAT3 expression in gastric carcinoma was significantly associated with tumor differentiation grade, lymph node metastasis, depth of invasion, and clinical stage （all P 0.05）. There was a significant negative relation between the expression of SOCS2 and that of STAT3 in gastric carcinoma （r =-0.486, P 0.01）. CONCLUSION： SOCS2 is lowly expressed in gastric carcinoma, while STAT3 is highly expressed in gastric carcinoma. Interaction between SOCS2 and STAT3 may contribute to gastric carcinogenesis.