炎症性肠病肝胆并发症的研究进展

Hepatobiliary complications of inflammatory bowel disease

炎症性肠病(inflammatory bowel disease,IBD)包括溃疡性结肠炎(ulcerative colitis,UC)和克罗恩病(Crohn's disease,CD),是一种免疫介导的慢性特发性胃肠道炎症性疾病,常伴随有肠外表现(extrainte stinal manifestations,EIMs),且涉及多个器官.肝胆系统病变是IBD常见的肠外表现,包括原发性硬化性胆管炎(primary sclerosing cholangitis,PSC)、非酒精性脂肪肝、胆石症、原发性胆汁性肝硬化(primary biliary cirrhosis,PBC)、小胆管性PSC、IgG4相关性胆管炎(IgG4-associated cholangitis,IAC)、肉芽肿性肝炎、淀粉样变性、自身免疫性肝炎(autoimmune hepatitis,AIH)、PSC/AIH重叠综合征和门静脉血栓形成等.本综述从IBD相关的肝胆并发症方面简述了该领域的研究进展,以期能为认识IBD相关肝病的发病机制和临床治疗提供新的启示.

Inflammatory bowel disease （IBD） is a chronic idiopathic immune-mediated inflammatory disease of the gastrointestinal tract, including ulcerative colitis （UC） and Crohn’s disease （CD）. Extraintestinal manifestations （EIMs） are frequently encountered in IBD patients. Hepatobiliary manifestations are common extraintestinal manifestations of IBD, including primary sclerosing cholangitis （PSC）, nonalcoholic fatty liver, cholelithiasis, primary biliary cirrhosis （PBC）, small-duct PSC, IgG4-associated cholangitis （IAC）, granulomatous hepatitis, amyloidosis, autoimmune hepatitis （AIH）, PSC/AIH overlap syndrome, and portal vein thrombosis. In this paper, we describe the progress in understanding the hepatobiliary complications associated with IBD.