内质网应激与肝脏疾病研究进展

Endoplasmic reticulum stress in liver disease

内质网应激是一种重要的细胞自我防御机制,内质网应激时,首先启动生存途径,但是持续的内质网应激将启动细胞凋亡途径.肝细胞内有大量的内质网,许多肝脏疾病均与内质网应激及其介导的细胞凋亡有关,如病毒性肝炎、酒精性肝病、非酒精性脂肪性肝病、药物性肝病、急性肝衰竭、肝癌等,针对内质网应激途径来进行凋亡保护或促进凋亡以寻找新靶点药物来治疗肝脏疾病在理论上成为可能.本文将从内质网应激反应的生存途径、凋亡途径,内质网应激及其介导的细胞凋亡在肝脏疾病发病机制中的作用以及在肝病干预治疗上的意义等方面进行综述.

Endoplasmic reticulum stress（ERS） is an important self-defense mechanism of the cell.ERS initially activates survival pathway,but sustained ERS will induce apoptosis.ERS and apoptosis induced by ERS are involved in the pathogenesis of many liver diseases,including viral hepatitis,alcohol-induced liver injury,nonalcoholic fatty liver disease,drug-induced liver disease,acute hepatic failure,and hepatocellular carcinoma.It is of important theoretical and practical significance for curing liver diseases to find some new drugs targeting ERS-induced apoptosis.The present review will discuss the survival and death pathways mediated by ERS,the role of ERS in the pathogenesis of hepatic diseases,and therapeutic interventions for these diseases.