脂代谢与结直肠肿瘤关系的研究进展

Advances in understanding the relationship between lipid metabolism and colorectal carcinoma

近年来结直肠肿瘤(colorectal carcinoma,CRC)的发病率和死亡率每年呈上升趋势,严重威胁着人类的健康.在对CRC的发生发展的研究中,脂代谢与CRC的关系受到人们的越来越多关注.目前研究发现高脂饮食更易导致CRC,而且血脂中的不同成分在CRC的形成和发展中,可能发挥了完全相反的作用,对于这些作用发生的机制有多种推测,还需要进一步的研究证实.因此,对于脂代谢异常对结直肠肿瘤的形成和进展中的作用及机制的研究对结直肠癌的诊断和治疗具有重要意义.

In recent years,the morbidity and mortality of colorectal carcinoma（CRC） have been increasing and it has become a serious threat to human health.In the research of the development of CRC,more and more researchers are concerned about the relationship between lipid metabolism and CRC.High-fat diets are more likely to cause CRC.Different types of lipids may play an opposite role in the formation and development of CRC.There are various hypotheses explaining the effect of lipid metabolism on the pathogenesis of CRC,and further studies are needed to confirm them.Elucidation of the relationship between lipid metabolism and CRC will be beneficial to the diagnosis and therapy of this malignancy.