上皮间质转化与肝纤维化的研究进展

Progress in understanding the relationship between epithelial-mesenchymal transition and liver fibrosis

上皮间质转化是一个复杂的病理生理过程,目前认为他在肝纤维化过程中起着重要的作用.现有研究表明肝上皮细胞(肝细胞、胆管上皮细胞、肝祖细胞)可以通过上皮间质转化而促进肝纤维化.该过程主要通过转化生长因子-β1信号通路调节,并涉及多种细胞因子的参与.本文就上皮间质转化与肝纤维化的关系作一综述.

Epithelial-mesenchymal transition（EMT） is a complicated pathophysiological process and is thought to play an important role in the pathogenesis of liver fibrosis recently.Evidence suggests that epithelial cells in the liver（hepatocytes,cholangiocytes and hepatic epithelial progenitors） may undergo EMT and contribute to liver fibrosis.EMT is regulated in liver fibrosis mainly through the transforming growth factor beta1 signaling pathway,and various cytokines are involved in this process.This review aims to elucidate the roles of EMT in the pathogenesis of liver fibrosis,